Potassium Hydroxide → HCID 23035828, compound

HRID 1710201Notes

Reaction equation

HRID 1710201 reaction equation
[CH2:1]([O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[NH:17][CH:16]=[C:15]([C:18]3[CH:23]=[CH:22][C:21]([O:24]C(=O)C)=[CH:20][CH:19]=3)[S:14]2)=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[OH-].[K+]>CO>[CH2:1]([O:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[NH:17][CH:16]=[C:15]([C:18]3[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=3)[S:14]2)=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 23035831HCID 23035831, compound

Product 1

HCID 23035828HCID 23035828, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2-(4-n-pentyloxyphenyl)-5-(4-acetyloxyphenyl)-thiadiazole 4.0 g (0.01 moles) was suspended in 40 mL methanol and mixed with a solution of 2.0 g KOH in 90 mL methanol. The mixture was heated for 2 hours under reflux. The solvent was subsequently distilled off in a rotary evaporator and the residue dissolved in 50 mL water. The solution was acidified with 5% HCl, and the precipitate formed was filtered off with suction and recrystallized from ethanol.

Workup

  1. temperatureThe mixture was heated for 2 hours
  2. temperatureunder reflux
  3. distillationThe solvent was subsequently distilled off in a rotary evaporator
  4. dissolutionthe residue dissolved in 50 mL water
  5. customthe precipitate formed
  6. filtrationwas filtered off with suction
  7. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-bfd2ece54e43432bbdcd5feebadff0b9
Source dataset
uspto-grants-1990_08
Patent number
US04952699

Reaction notes

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