HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → (3S,4R)-4-(4-p-nitrobenzyloxycarbonylaminobutyrylthio)-3-methoxy-2-oxoazetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (3S,4S)-4-acetoxy-3-methoxy-2-oxoazetidine | HCID 56607243 | — |
| Reactant | HCID 178523351 | HCID 178523351 | — |
| Solvent | Phosphate | HCID 1061 | — |
| Product | (3S,4R)-4-(4-p-nitrobenzyloxycarbonylaminobutyrylthio)-3-methoxy-2-oxoazetidine | HCID 18609679 | — |
Reaction Steps
Analogously to Example 55b), an aqueous solution of 480 mg of 4-p-nitrobenzyloxycarbonylaminothiobutyric acid sodium salt is added to 159 mg of (3S,4S)-4-acetoxy-3-methoxy-2-oxoazetidine in 6 ml of a phosphate buffer of a pH of 7 and 0.4 ml of dioxan After working up and chromatography over silica gel, the title compound with the following IR spectrum (CH2Cl2) is obtained: characteristic absorption bands at 2.95, 5.6, 5.78, 5.87, 6.56, 7.41 and 8.26μ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952690 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-59e9568b5d694ddeb2c1d1ae37fce468 |
| Source note | uspto-grants-1990_08 |