2-Chloro-1-(2,5-dimethylphenyl)propan-1-one → 4,7-Dimethyl-1-indanone

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Reaction Steps

The crude 2-(2-chloropropionyl)-1,4-dimethylbenzene was slowly added to concentrated sulfuric acid (400 ml), preheated to 105° C. The solution was then stirred at 105°-110° C. for 30 minutes. The cooled mixture was poured onto cracked ice and the precipitate collected to give 4,7-dimethylindan-1-one (59.4 g, 65.6%) as a pale solid, mp 70° C.

Provenance & Evidence