Nitric Acid → HCID 135848689, compound

HRID 1710329Notes

Reaction equation

HRID 1710329 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:17])=[C:6]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=[O:15])[CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[N+:18]([O-])([OH:20])=[O:19]>C(O)(=O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]([N+:18]([O-:20])=[O:19])[C:5]([OH:17])=[C:6]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=[O:15])[CH:11]=[CH:10][CH:9]=2)[CH:7]=1

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 135848690HCID 135848690, compound

Product 1

HCID 135848689HCID 135848689, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

To the solution of 6-(5-chloro-2-hydroxyphenyl)-pyridine-2-carboxylic acid; (2.3 g, 10.1 mmol) in 100 ml acetic acid; was added 1 ml fuming nitric acid; and stirred at 35° C. to 40° C. for half an hour. The reaction mixture was diluted with water and adjusted pH to 2.5. The resulting precipitation was collected, washed and dried to give solid (2.74 g; 78%, three steps). MS (ES) m/z 295 [M+H].

Workup

  1. additionwas added 1 ml
  2. customThe resulting precipitation
  3. customwas collected
  4. washwashed
  5. customdried
  6. customto give solid (2.74 g; 78%, three steps)

Sources & evidence

ORD record
ord-c2beebefcb2e4fd1a0f74cd9cf3b3344
Source dataset
uspto-grants-2010_09
Patent number
US07790704B2

Reaction notes

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