Isopropylamine → 5-[(1-Methylethyl)amino]-1-phenyl-N-tricyclo[3.3.1.13,7]dec-2-yl-1H-pyrazole-4-carboxamide

HRID 1710340Notes

Reaction equation

HRID 1710340 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1Cl)=[O:13])[CH2:8]2.[CH:26]([NH2:29])([CH3:28])[CH3:27]>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1[NH:29][CH:26]([CH3:28])[CH3:27])=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 575502625-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide2×

Product 1

HCID 252049365-[(1-Methylethyl)amino]-1-phenyl-N-tricyclo[3.3.1.13,7]dec-2-yl-1H-pyrazole-4-carboxamide

Procedure

5-Isopropylamino-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide was prepared using Procedure A from 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Intermediate 3) and isopropylamine. Mass spectrum (ES) MH+=379.

Sources & evidence

ORD record
ord-233992fb5eed4f60bddfe6a257bc8fac
Source dataset
uspto-grants-2010_09
Patent number
US07790711B2

Reaction notes

Loading…