3-Pyridinemethanamine → Phenyl-5-[(pyridin-3-ylmethyl)-amino]-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

HRID 1710342Notes

Reaction equation

HRID 1710342 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1Cl)=[O:13])[CH2:8]2.[NH2:26][CH2:27][C:28]1[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=1>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1[NH:26][CH2:27][C:28]1[CH:29]=[N:30][CH:31]=[CH:32][CH:33]=1)=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 310183-PyridinemethanamineHCID 575502625-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide2×

Product 1

HCID 25204938Phenyl-5-[(pyridin-3-ylmethyl)-amino]-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

Procedure

Phenyl-5-[(pyridin-3-ylmethyl)-amino]-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide was prepared using Procedure A from 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Intermediate 3) and 3-(aminomethyl)pyridine. Mass spectrum (ES) MH+=428.

Sources & evidence

ORD record
ord-bbb01f2ad51c41e7a940c36ae82a306d
Source dataset
uspto-grants-2010_09
Patent number
US07790711B2

Reaction notes

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