4-Hydroxypyrrolidine → HCID 25204052, compound

HRID 1710358Notes

Reaction equation

HRID 1710358 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1Cl)=[O:13])[CH2:8]2.[CH2:26]1[CH:30]([OH:31])[CH2:29][NH:28][CH2:27]1>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([C:14]1[CH:15]=[N:16][N:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]=1[N:28]1[CH2:27][CH2:26][CH:30]([OH:31])[CH2:29]1)=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 575502625-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide2×

Product 1

HCID 25204052HCID 25204052, compound

Procedure

5-(3-Hydroxy-pyrrolidin-1-y1)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide was prepared using Procedure A from 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Intermediate 3) and DL-3-pyrrolidinol. Mass spectrum (ES) MH+=407.

Sources & evidence

ORD record
ord-c8e4a7e7fd744da7a0d16bb7cc42be8a
Source dataset
uspto-grants-2010_09
Patent number
US07790711B2

Reaction notes

Loading…