HRID1710367

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

结构：COc1ccc(-c2cnc3[nH]c(CCC4CCCCC(=S)N4)nc3c2)cc1

HCID178488745

未命名化合物

2 次

结构：NC1=NC(CCc2nc3cc(-c4ccccc4)cnc3[nH]2)CCCC1

HCID178508386

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(-c2cnc3[nH]c(CCC4CCCCC(N)=N4)nc3c2)cc1

HCID178488743

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The title compound is synthesized as described for 7-[2-(6-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-4,5,6,7-tetrahydro-3H-azepin-2-ylamine (compound 1) from 98 mg of 7-{2-[6-(4-methoxy-phenyl)-3H-imidazo[4,5-b]pyridin-2-yl]-ethyl}-azepane-2-thione (compound A3) and 6.0 ml of methanol containing ammonia (strength: 7.0 M) at 50° C. for 5 days. Purification by flash chromatography on LiChroprep-NH2® (eluent: ethanol) affords 23 mg of the title compound as an amorphous, colorless solid of m.p. 306° C. ESI-MS: 364.2 (MH+). TLC: Rf=0.50 (LiChroprep-NH2® HPTLC, methanol/water 10:1 parts by volume).

WORKUP

后处理

customThe title compound is synthesized
customPurification by flash chromatography on LiChroprep-NH2® (eluent: ethanol)