反应详情

The title compound is synthesized as described for 7-[2-(6-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-4,5,6,7-tetrahydro-3H-azepin-2-ylamine (compound 1) from 71 mg of 4-{2-[2-(7-thioxo-azepan-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridin-6-yl}-N-o-tolyl-benzenesulfonamide (compound A9) and 3.2 ml of methanol containing ammonia (strength: 7.0 M) at 50° C. for 66 hours. Subsequently, the solution is concentrated in vacuo to yield 60 mg of the pure title compound as an amorphous, colorless solid of m.p. 215° C. ESI-MS: 503.4 (MH+), TLC: Rf=0.25 (HPTLC RP-C18; acetonitrile/water 2:1 parts by volume).

1. customThe title compound is synthesized
2. concentrationSubsequently, the solution is concentrated in vacuo