4-bromo-N-methyl-N-(tetrahydro-furan-2-ylmethyl)-benzenesulfonamide → HCID 178482879, compound

Participants

Role	Name	HCID	Charge
Reactant	4-bromo-N-methyl-N-(tetrahydro-furan-2-ylmethyl)-benzenesulfonamide	HCID 61059994	—
Reactant	HCID 178516005	HCID 178516005	—
Reactant	7-(2-{6-[4-(azetidine-1-sulfonyl)-phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}-ethyl)-azepan-2-one	HCID 178516007	—
Product	HCID 178482879	HCID 178482879	—

Reaction Steps

The title compound is synthesized as described for 7-(2-{6-[4-(azetidine-1-sulfonyl)-phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}-ethyl)-azepan-2-one (compound B6) from 458 mg of 4-bromo-N-methyl-N-(tetrahydro-furan-2-ylmethyl)-benzenesulfonamide (compound C7) and 300 mg of 7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-azepan-2-one (compound C1). Purification by chromatography on flash silica gel (eluent gradient: dichloromethane/0-20 vol. % ethanol) yields 174 mg of the title compound as a waxy solid. ESI-MS: 512.4 (MH+). TLC: Rf=0.30 (dichloromethane/ethanol 10:1 parts by volume).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07790710B2
Source dataset	uspto-grants-2010_09
ORD ID	ord-6c589fc5e96c49088af1109abc3b2758
Source note	uspto-grants-2010_09