HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Bromobenzenesulfonyl chloride → 4-bromo-N-(2-fluoro-4-methylphenyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Bromobenzenesulfonyl chloride | HCID 7396 | — |
| Reactant | 2-Fluoro-4-methylaniline | HCID 67984 | — |
| Reactant | 1-((4-Bromophenyl)sulfonyl)azetidine | HCID 7213242 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Potassium Carbonate | HCID 11430 | — |
| Product | 4-bromo-N-(2-fluoro-4-methylphenyl)benzenesulfonamide | HCID 26979418 | — |
Reaction Steps
The title compound is analogously synthesized as described for 1-(4-bromo-benzenesulfonyl)-azetidine (compound C3) from 767 mg of 4-bromo-benzenesulfonyl chloride, 451 mg of commercially available 2-fluoro-4-methyl-aniline in 12.0 ml of dichloromethane and 6.0 ml of K2CO3 solution to yield 727 mg of the title compound as colorless, amorphous solid of m.p. 111° C. ESI-MS: 361.2/363.3 (MNH4+, 100%:87%). TLC: Rf=0.57 (neat dichloromethane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790710B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-1c6d1093e30144de95c330d34c3d33ee |
| Source note | uspto-grants-2010_09 |