Potassium Hydroxide → HCID 58767558, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1b (Example 1) (33 mg, 0.09 mmol) in EtOH (2 mL) was added 10% of aqueous KOH (174 uL, 0.35 mmol). The mixture was heated to 80° C. for 3 h. The reaction was cooled to room temperature and concentrated. The resulting residue was dissolved in water (7 mL) and acidified with 6 N HCl to pH ˜2. A large amount of white precipitate formed which was filtered and rinsed with ether and dried in the vacuum oven (50° C.) to provide 18 mg of the title compound, yield 57%. ESI-MS m/z 362.37 [M−H]−.

Provenance & Evidence