Pyridine → HCID 10003159, compound

HRID 1710468Notes

Reaction equation

HRID 1710468 reaction equation
N1C=CC=CC=1.[CH2:7]([O:9][C:10]1[CH:11]=[C:12]([C:18]2[CH2:23][CH2:22][CH2:21][NH:20][N:19]=2)[CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[CH3:8].Cl.[CH3:25][C:26]1[N:27]=[C:28]([C:34]2[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=2)[S:29][C:30]=1[C:31](Cl)=[O:32]>C(Cl)Cl>[CH2:7]([O:9][C:10]1[CH:11]=[C:12]([C:18]2[CH2:23][CH2:22][CH2:21][N:20]([C:31]([C:30]3[S:29][C:28]([C:34]4[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=4)=[N:27][C:26]=3[CH3:25])=[O:32])[N:19]=2)[CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[CH3:8]

Participants

5

Reactant 3

HCID 1049PyridineHCID 115938543-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazineHCID 23467903HCID 23467903, compound

Product 1

HCID 10003159HCID 10003159, compoundYield 89.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1 ml of pyridine is added to a solution of 1.1 g of 3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazine in 20 ml of DCM, and 1.2 g of 4-methyl-2-pyridin-3-ylthiazole-5-carbonyl chloride, hydrochloride (“BA”) are subsequently added, and the mixture is stirred at room temperature for a further 16 hours. Conventional work-up gives 1.7 g of 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-pyridin-3-ylthiazol-5-yl)methanone.

Workup

  1. additionare subsequently added

Sources & evidence

ORD record
ord-c12a4f1442a64e68a9fde9d694099ecb
Source dataset
uspto-grants-2010_09
Patent number
US07790723B2

Reaction notes

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