3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazine → HCID 10321095, compound

HRID 1710471Notes

Reaction equation

HRID 1710471 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]2[CH2:17][CH2:16][CH2:15][NH:14][N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2].[CH3:18][C:19]1[N:20]=[C:21]([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)[S:22][C:23]=1[C:24](Cl)=[O:25]>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]2[CH2:17][CH2:16][CH2:15][N:14]([C:24]([C:23]3[S:22][C:21]([C:27]4[S:28][CH:29]=[CH:30][CH:31]=4)=[N:20][C:19]=3[CH3:18])=[O:25])[N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]

Participants

3

Reactant 2

HCID 115938543-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazineHCID 77230316HCID 77230316, compound

Product 1

HCID 10321095HCID 10321095, compoundYield 78.7%

Procedure

Analogously to Example 2, reaction of 1.04 g of 3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro4H-pyridazine with 1.08 g of 4-methyl-2-thiophen-2-ylthiazole-5-carbonyl chloride (“CA”) gives the compound 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(4-methyl-2-thiophen-2-ylthiazol-5-yl)methanone (1.54 g).

Sources & evidence

ORD record
ord-d95a7798d6b44d4c8fbd6c6e0a5f0d42
Source dataset
uspto-grants-2010_09
Patent number
US07790723B2

Reaction notes

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