反应详情

33 g of 4-(2-Methoxy-5-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (97.8 mmol) were dissolved in 450 mL of methanol. 3 g of 10% Pd/C were added at room temperature under nitrogen atmosphere, and the reaction mixture was hydrogenated for 4 h. The reaction mixture was filtered over Celite, the was solvent evaporated and the remaining residue was treated with 100 mL of diisopropylether. Once crystallization started, the solvent was removed under reduced pressure and the remaining product dried thoroughly. This material was used in subsequent steps without further purification.

1. filtrationThe reaction mixture was filtered over Celite
2. customthe was solvent evaporated
3. additionthe remaining residue was treated with 100 mL of diisopropylether
4. customOnce crystallization
5. customthe solvent was removed under reduced pressure
6. customthe remaining product dried thoroughly
7. customThis material was used in subsequent steps without further purification