3-(Difluoromethoxy)benzenesulfonyl chloride → HCID 67094804, compound

HRID 1710623Notes

Reaction equation

HRID 1710623 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:21][CH:22]([F:34])[O:23][C:24]1[CH:25]=[C:26]([S:30]([Cl:33])(=[O:32])=[O:31])[CH:27]=[CH:28][CH:29]=1>>[ClH:33].[F:34][CH:22]([F:21])[O:23][C:24]1[CH:25]=[C:26]([S:30]([NH:20][C:18]2[CH:17]=[CH:16][CH:15]=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=2)(=[O:32])=[O:31])[CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 27782263-(Difluoromethoxy)benzenesulfonyl chlorideHCID 22330182tert-Butyl 4-(3-aminophenyl)piperazine-1-carboxylate

Product 1

HCID 67094804HCID 67094804, compound

Procedure

The compound was prepared as described for Example 1 by reaction of 4-(5-aminophenyl)-piperazine-1-carboxylic acid tert-butyl ester with commercially available 3-difluoromethoxybenzene sulfonylchloride followed by deprotection under acidic conditions.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-047de5932933433b8f8093e0556782fd
Source dataset
uspto-grants-2010_09
Patent number
US07790727B2

Reaction notes

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