HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (6-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl chloroacetate | HCID 7751 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 6-Chloro-2,3-dihydrobenzoxazol-2-one | HCID 29858 | — |
| Solvent | Lithium Hydroxide | HCID 3939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (6-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid | HCID 776366 | — |
Reaction Steps
(6-Chloro-2-oxo-benzooxazol-3-yl)-acetic acid was prepared by heating 6-chloro-3H-benzooxazol-2-one and ethyl chloroacetate in the presence of cesium carbonate in DMF at 60° C. The crude residue was dissolved followed in 1N LiOH in THF and stirred at rt. The resultant mixture was acidified with 1N HCl to pH ˜1. The desired product precipitated out of solution and was isolated by filtration, and used directly in subsequent reactions without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790726B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-7a96ee914095404aae96e68055f0de20 |
| Source note | uspto-grants-2010_09 |