4-Fluorobenzoyl chloride → HCID 16070216, compound

HRID 1710705Notes

Reaction equation

HRID 1710705 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[C:10]([NH2:12])[CH:9]=[N:8][C:7]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1.[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH:12][C:10]2[CH:9]=[N:8][C:7]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[N:11]=2)=[O:25])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 59457582HCID 59457582, compound

Product 1

HCID 16070216HCID 16070216, compoundYield 45%

Procedure

Obtained as a solid (50 mg, 45%) from 6-(2-furyl)-5-pyridin-4-ylpyrazin-2-amine (Example 5) and 4-fluorobenzoyl chloride following the procedure of Example 15 (step b).

Sources & evidence

ORD record
ord-922fb9e30d9f4dbf8769ed2285a1c251
Source dataset
uspto-grants-2010_09
Patent number
US07790728B2

Reaction notes

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