HCID 59457653, compound → HCID 16070570, compound

HRID 1710715Notes

Reaction equation

HRID 1710715 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[N:12][C:11]3=[N:20]S[N:22]=[C:10]3[N:9]=2)[CH:5]=[CH:6][CH:7]=1>N.O>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[C:10]([NH2:22])[C:11]([NH2:20])=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 59457653HCID 59457653, compound

Product 1

HCID 16070570HCID 16070570, compoundYield 48%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 962WaterSolvent

Procedure

A mixture of 5-(3-fluorophenyl)-6-pyridin-4-yl[1,2,5]thiadiazolo[3,4-b]pyrazine (Preparation 11) (1.6 g, 5.2 mmol) in ammonia solution (32%, 30 mL) was stirred and heated under reflux for 1 h. The reaction was allowed to cool to room temperature, diluted with water and the suspension obtained was filtered to provide the title compound as a brown solid (0.7 g, 48%).

Workup

  1. temperatureheated
  2. temperatureunder reflux for 1 h
  3. customthe suspension obtained
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-ade0211c6440456bafad8c3fb8643360
Source dataset
uspto-grants-2010_09
Patent number
US07790728B2

Reaction notes

Loading…