Sodium Bicarbonate → HCID 178508291, compound

Participants

Reaction Steps

To a cooled solution (0° C.) of 5-(3-fluorophenyl)-6-pyridin-4-ylpyrazine-2,3-diamine (Example 72, 100 mg, 0.36 mmol) in HCl 1N (1 mL) was added dropwise a solution of sodium nitrite (35 mg, 0.50 mmol) in water (0.6 mL). The reaction was stirred for 1 h at room temperature and after this period was driven to pH7 by addition of a NaHCO3 4% solution. The suspension was filtered to leave a solid which was purified by silica gel chromatography eluting with CH2Cl2/MeOH/NH3 (50:8:1) to afford the title compound (37 mg, 36%).

Provenance & Evidence