Ethyl orthoformate → HCID 178505656, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3-fluorophenyl)-6-pyridin-4-ylpyrazine-2,3-diamine (Example 72, 300 mg, 1.07 mmol) in 1,1′,1″-[methanetriyltris(oxy)]triethane (3 mL) was stirred and heated at 140° C. overnight. The solvent was removed under vacuum and the residue was triturated with diethyl ether. The resulting solid was purified by silica gel column chromatography (CH2Cl2/MeOH 9:1) to afford the title compound as a yellow solid (136 mg, 44%)

Provenance & Evidence