Water → HCID 178432379, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3-fluorophenyl)-6-pyridin-4-ylpyrazine-2,3-diamine (Example 72, 300 mg, 1.07 mmol) in acetic anhydride (3 mL) was stirred and heated at 140° C. for 4 h. Then polyphosphoric acid was added (0.32 g) and allowed to react at the same temperature for 2 h. Upon cooling, water was added and the product extracted with ethyl acetate. The crude obtained was purified by silica column chromatography eluting with a gradient from CH2Cl2 to CH2Cl2/MeOH 95:5 to afford the title compound as a yellow solid (36 mg, 52%).

Provenance & Evidence