HCID 16070453, compound → HCID 16070834, compound

Participants

Reaction Steps

A mixture of potassium t-butoxide (45 mg, 0.40 mmol) in N-methylpyrrolidone (1 mL) was stirred under nitrogen and a solution of 3-ethynyl-6-(2-furyl)-5-pyridin-4-ylpyrazin-2-amine (Example 65, 50 mg, 0.19 mmol) in N-methylpyrrolidone (1 mL) was added. The mixture was stirred at room temperature overnight, partitioned between water and ethyl acetate, the aqueous phase was extracted twice with ethyl acetate, the organic extracts washed with water and brine, dried (MgSO4) and concentrated under vacuum. Silica gel flash column chromatography (dichloromethane/methanol 95:5) gave the title compound as a yellow solid (20 mg, 40%).

Provenance & Evidence