Sodium Hydroxide → HCID 59457559, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 4-[2-(3-fluoropyridin-4-yl)-3-pyridin-3-yl-5H-pyrrolo[2,3-b]pyrazin-6-yl]benzonitrile (Example 150) (0.050 g, 0.12 mmol) in ethanol (1.5 mL) was added a 2N aqueous solution of sodium hydroxide (0.127 mL, 0.25 mmol) and the mixture was stirred at 80° C. After 18 h, ethanol was evaporated and the aqueous phase was acidified until pH=6 with a 2N aqueous solution of hydrochloric acid. The resulting solid was filtered, washed with water and dried to furnish the titled compound (0.018 g, 36%) as a brown solid.

Provenance & Evidence