2,3-Difluorobenzoic acid → 2-Fluorobenzoic acid

HRID 1710733Notes

Reaction equation

HRID 1710733 reaction equation
FC1C=CC=CC=1C1NC2C(=NC=NC=2)N=1.[F:17][C:18]1[C:26](F)=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([OH:22])=[O:21]>>[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([OH:22])=[O:21]

Participants

3

Reactant 2

HCID 3705902,3-Difluorobenzoic acidHCID 469416118-(2-Fluorophenyl)-7H-purine

Product 1

HCID 99352-Fluorobenzoic acidYield 45.7%

Procedure

Synthesized as described above for 8-(2-fluorophenyl)-purine, except that 2,3-difluorobenzoic acid was used instead of 2-fluorobenzoic acid (white powder, yield: 45.7%)

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-9f7c9c1853a84af0bfc7a02e79671ce6
Source dataset
uspto-grants-2010_09
Patent number
US07790730B2

Reaction notes

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