1,3-Dichloroacetone → HCID 59457464, compound

Participants

Reaction Steps

A mixture of 4-(3-chloropropoxy)benzamide ax54 (1.9 g, 8.9 mmol, 1 eq), 1,3-dichloro-propan-2-one (1.13 g, 8.9 mmol, 1 eq) in propionitrile (45 ml) is stirred at reflux for 48 h. The solvent is then removed under vacuum and filtered over silicagel with dichloromethane. The dichloromethane is evaporated under vacuum to give 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-1,3-oxazole ax57 (2.1 g) as a white solid.

Provenance & Evidence