Sodium Iodide → HCID 11857307, compound

Participants

Reaction Steps

A mixture of 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-1,3-oxazole ax57 (0.172 g, 0.6 mmol, 1 eq), sodium iodide (0.018 g, 0.12 mmol, 0.2 eq), potassium carbonate (0.373 g, 2.7 mmol, 4.5 eq) and 2-methylpyrrolidine in acetonitrile (5 ml) is stirred at room temperature for 72 h. Piperidine (0.05 g, 0.6 mmol, 1 eq) is then added and the mixture is stirred at 80° C. overnight. The volatiles are then removed under vacuum and the residue is purified by chromatography (dichloromethane/methanol/ammonia 96:3.6:0.4) to give 1-[3-(4-{4-[(2-methylpyrrolidin-1-yl)methyl]-1,3-oxazol-2-yl}phenoxy)propyl]piperidine 30 as a pale yellow oil.

Provenance & Evidence