Lithium hydroxide, monohydrate → HCID 59457517, compound

Participants

Reaction Steps

A solution of lithium hydroxide hydrate (0.76 g, 18.11 mmol, 2 eq) in water (10 ml) is added to a solution of methyl {2-[4-(3-chloropropoxy)phenyl]-1,3-oxazol-4-yl}acetate ax62 (2.8 g, 9.06 mmol, 1 eq) in tetrahydrofuran (100 ml). The mixture is stirred at room temperature for 1 h. The mixture is then poured into water and extracted with diethyl ether (2×75 ml). The aqueous layer is acidified with 6 N aqueous hydrochloric acid and extracted with ethyl acetate. The organic layer is dried over magnesium sulfate and concentrated under vacuum to give 2.1 g of {2-[4-(3-chloropropoxy)phenyl]-1,3-oxazol-4-yl}acetic acid ax63 as a brown solid.

Provenance & Evidence