1-Bromo-3-chloropropane → HCID 59457498, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-bromo-3-chloropropane (0.7 mmol, 2 eq, 11.5 mg), potassium carbonate (0.7 mmol, 2 eq, 98 mg) and 4-{4-[(2-methylpyrrolidin-1-yl)methyl]-1,3-oxazol-2-yl}phenol ax65 (0.35 mmol, 1 eq, 91.5 mg) in acetone (1.25 ml) is stirred at 56° C. overnight. The mixture is then filtered, washed with acetone (2×500 μl), and the solvent is removed under reduced pressure. The residue is dissolved in 3.5 ml of dichloromethane and washed twice with water (2×3.5 ml) and finally with brine (3.5 ml). The organic layer is dried over magnesium sulfate, filtered and the solvent is removed under reduced pressure. The crude product is used directly in the next step.

Provenance & Evidence