2-Butanone, 3-bromo- → HCID 59457487, compound

Participants

Reaction Steps

A suspension of 4-(3-chloropropoxy)benzamide ax54 (1.2 g, 5.62 mmol) and 3-bromobutan-2-one (1.02 g, 6.74 mmol) is heated in propionitrile (50 ml) at reflux for 10 days. The mixture is then concentrated and the resulting black mixture is filtered through a pad of silicagel, eluting first with dichloromethane (100 ml) and then with a 96:4 mixture of dichloromethane and dimethoxymethane to afford two fractions. The second fraction is concentrated, and the resulting yellow solid (0.67 g) is further purified by chromatography over silicagel (eluent: dichloromethane) to afford 330 mg of 2-[4-(3-chloropropoxy)phenyl]-4,5-dimethyl-oxazole i30 as a pale yellow solid.

Provenance & Evidence