Hydrochloric Acid → HCID 59457455, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-oxazole-5-carboxylate ax60 (4.0 g, 12.9 mmol, 1 eq) in a 1:1 mixture of methanol and water (100 ml) is treated with a 1 M solution of sodium hydroxide (14 ml, 14 mmol, 1.1 eq). The mixture is stirred at 60° C. during 2 h, then the mixture is concentrated. The residue is taken up in water (20 ml) and a 1 M hydrochloric acid solution (14 ml, 14 mmol, 1.1 eq) is added. The resulting suspension is filtered and the filtrate is concentrated to give 3.4 g of 2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-oxazole-5-carboxylic acid i43.

Provenance & Evidence