Methyl 4-chloroacetoacetate → HCID 136046543, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-hydroxybenzamide (10 g, 7.3 mmol, 1 eq) and methyl 4-chloro-3-oxobutanoate (15 g, 11 mmol, 5 eq) in propionitrile (300 ml) is stirred at reflux (98° C.) during 3 days. After concentration under reduced pressure, the residue is purified over silicagel (eluent: dichloromethane/methanol/ammonia 90:9:1) to yield 7 g of methyl[2-(4-hydroxyphenyl)-1,3-oxazol-4-yl]acetate i50.

Provenance & Evidence