1-Bromo-2-Chloroethane → HCID 59457508, compound

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Reaction Steps

A mixture of methyl[2-(4-hydroxyphenyl)-1,3-oxazol-4-yl]acetate 150 (1 g, 4.29 mmol, 1 eq), potassium carbonate (2.37 g, 17.16 mmol, 4 eq) and 1-bromo-2-chloroethane (1.54 g, 10.7 mmol, 2.5 eq) in acetone (50 ml) is stirred at reflux for 140 h. Potassium carbonate is then filtered off and the solvent is evaporated. The residue is taken up in ethyl acetate and washed two times with an aqueous solution of sodium hydrogenocarbonate. The organic layer is dried over magnesium sulfate, filtered and concentrated under vacuum to give 1.1 g of methyl {2-[4-(2-chloroethoxy)phenyl]-1,3-oxazol-4-yl}acetate i51.

Provenance & Evidence