Sodium Hydroxide → HCID 59457491, compound

Participants

Reaction Steps

A 2 N aqueous sodium hydroxide solution (2.6 ml, 5.23 mmol, 6 eq) is added to a solution of methyl (2-{4-[2-(2-methylpyrrolidin-1-yl)ethoxy]phenyl}-1,3-oxazol-4-yl)acetate 152 (0.3 g, 0.87 mmol, 1 eq) in ethanol (15 ml). The mixture is stirred at reflux for 3 h and the solvent is then evaporated. The residue is taken up in water, acidified with 2 N hydrochloric acid and the solvent is evaporated under reduced pressure to give 0.8 g of (2-{4-[2-(2-methylpyrrolidin-1-yl)ethoxy]phenyl}-1,3-oxazol-4-yl)acetic acid i53 together with remaining sodium chloride. The compound is used in the next step without any other treatment.

Provenance & Evidence