Diethyl Ether → HCID 136046541, compound

Participants

Reaction Steps

To a solution of 1-({2-[4-(benzyloxy)-3-chlorophenyl]-1,3-oxazol-4-yl}methyl)piperidine i61 (0.3 g, 0.78 mmol, 1 eq) in dodecanethiol (5 ml) is added dropwise boron trifluoride diethyl etherate (1.59 ml, 12.54 mmol, 48 eq). The mixture is stirred at room temperature for 60 h. Diethyl ether is poured onto the mixture and the solid that precipitates is filtered off and recrystallized from diethyl ether to give 150 mg of 2-chloro-4-[4-(piperidin-1-ylmethyl)-1,3-oxazol-2-yl]phenol i66.

Provenance & Evidence