1-Bromo-3-chloropropane → HCID 59457458, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-chloro-4-[4-(piperidin-1-ylmethyl)-1,3-oxazol-2-yl]phenol i66 (0.13 g, 0.44 mmol, 1 eq), 1-bromo-3-chloropropane (57 μl, 0.58 mmol, 1.3 eq) and potassium carbonate (0.12 g, 0.89 mmol, 2 eq) is stirred at 50° C. overnight. The carbonate is then filtered off and the resulting solution is concentrated under reduced pressure to give 0.12 g of crude 1-({2-[3-chloro-4-(3-chloropropoxy)phenyl]-1,3-oxazol-4-yl}methyl)piperidine i71 as an oil, which is directly used in the next step.

Provenance & Evidence