Thionyl Chloride → HCID 59457513, compound

HRID 1710774Notes

Reaction equation

HRID 1710774 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[C:8]([F:15])[CH:7]=1.S(Cl)([Cl:18])=O>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([Cl:18])=[O:11])=[C:8]([F:15])[CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 59457485HCID 59457485, compound

Product 1

HCID 59457513HCID 59457513, compound

Procedure

4-(3-chloropropoxy)-2-fluorobenzoic acid i78 (0.68 g, 2.92 mmol, 1 eq) is refluxed in thionyl chloride (4.27 ml, 57.46 mmol, 20 eq) for 3 hours. The mixture is then concentrated under reduced pressure to give 0.73 g of crude 4-(3-chloropropoxy)-2-fluorobenzoyl chloride i80, which is used in the next step without purification.

Workup

  1. concentrationThe mixture is then concentrated under reduced pressure

Sources & evidence

ORD record
ord-fb09326b2efd41a3a2efa41afe228d10
Source dataset
uspto-grants-2010_09
Patent number
US07790720B2

Reaction notes

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