Ammonia → HCID 59457468, compound

HRID 1710775Notes

Reaction equation

HRID 1710775 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10](Cl)=[O:11])=[C:8]([F:15])[CH:7]=1.[NH3:16]>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([NH2:16])=[O:11])=[C:8]([F:15])[CH:7]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 59457513HCID 59457513, compound

Product 1

HCID 59457468HCID 59457468, compoundYield 61%

Procedure

4-(3-chloropropoxy)-2-fluorobenzoyl chloride i80 (0.73 g, 2.91 mmol, 1 eq) is treated with aqueous ammonia (35 ml) and the resulting mixture is vigorously stirred at room temperature overnight. The mixture is then filtered to give 0.41 g of 4-(3-chloropropoxy)-2-fluorobenzamide i82 as a white solid.

Workup

  1. filtrationThe mixture is then filtered

Sources & evidence

ORD record
ord-adc5803454b446bb9e09f6f69ceee70f
Source dataset
uspto-grants-2010_09
Patent number
US07790720B2

Reaction notes

Loading…