N-bromobutanimide → HCID 59457457, compound

Participants

Reaction Steps

A solution of 4-(chloromethyl)-2-[4-(3-chloropropoxy)phenyl]-1,3-oxazole ax57 (0.5 g, 1.75 mmol, 1 eq) and N-bromosuccinimide (0.31 g, 1.75 mmol, 1 eq) in acetonitrile (16 ml) is stirred at 22° C. for 30 minutes. A heavy white precipitate forms during the reaction. The suspension is then filtered, the solid is washed with the minimum amount acetonitrile, collected and dried under vacuum at 40° C. to yield 290 mg of the title compound. The acetonitrile solution is concentrated to half its original volume to yield an additional 110 mg of 5-bromo-2-[4-(3-chloropropoxy)-phenyl]-4-chloromethyl-oxazole i89.

Provenance & Evidence