反应详情

温度

70 °C

A mixture of 4-(3-chloropropoxy)benzenecarbothioamide ax71 (34.67 mmol, 1 eq, 7.96 g), and 2-chloroacetoacetic acid methyl ester (34.67 mmol, 1 eq, 5.2 g) in methanol is stirred at 70° C. for 2 hours. The reaction mixture is then poured into a sealed tube and stirred at 100° C. for 3 hours. The mixture is taken up in dichloromethane and washed with water then dried over magnesium sulfate. The solvent is removed under reduced pressure to give 11.8 g of methyl 2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate i105. The product is used as such in the next step.

1. additionThe reaction mixture is then poured into a sealed tube
2. stirringstirred at 100° C. for 3 hours
3. washwashed with water
4. dry with materialthen dried over magnesium sulfate
5. customThe solvent is removed under reduced pressure