Sodium Hydroxide → HCID 59457499, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate i105 (14.1 mmol, 1 eq, 4.6 g) and 2 M sodium hydroxide (28.2 mmol, 2 eq, 14.1 ml) in methanol (100 ml) is stirred at 70° C. overnight. The mixture is concentrated to dryness and taken up in a minimum of water. The aqueous phase is acidified by 1 N hydrogen chloride to reach pH 2 and poured into ice to afford precipitation of a white solid. The solid is filtered and dried under reduced pressure to give 3.9 g of 2-[4-(3-chloropropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid i106 as a white solid. This solid is used as such in the next step.

Provenance & Evidence