Methyl iodide → HCID 178503338, compound

HRID 1710808Notes

Reaction equation

HRID 1710808 reaction equation
[CH3:1][I:2].[Cl:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]([CH3:15])[NH:7][C:8](=[S:14])[NH:9]2>CC(C)=O>[IH:2].[Cl:3][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]([CH3:15])[NH:7][C:8]([S:14][CH3:1])=[N:9]2

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86609751HCID 86609751, compound

Product 1

HCID 178503338HCID 178503338, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Methyl iodide (1.16 ml, 19 mmol) was added to a suspension of 5-chloro-4-methyl-3,4-dihydro-1H-quinazoline-2-thione (1.32 g, 6.2 mmol) in acetone (15 ml), and the mixture was stirred at r.t. over the weekend (the reaction is usually complete after 12 h). The precipitated product (2.08 g, 87%) was sufficiently pure for the next step.

Sources & evidence

ORD record
ord-cadcc21c206042fdaeddda56346e1729
Source dataset
uspto-grants-2010_09
Patent number
US07790732B2

Reaction notes

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