Hydrochloric Acid → HCID 86609752, compound

Participants

Reaction Conditions

Reaction Steps

At a temperature of 65° C., sodium borohydride (0.13 g, 3.4 mmol) was added to a solution of 1-(2-amino-3,6-dichloro-phenyl)-ethanone (1.16 g, 5.7 mmol) in ethanol (12 ml), and the mixture was heated overnight (65° C.). Water (14.4 ml), KSCN (0.61 g, 6.3 mmol) and concentrated aqueous hydrogen chloride solution (3.6 ml) were then added subsequently, and the mixture was again heated (3 h, 65° C.). The majority of the title compound precipitated upon cooling and could be isolated in pure form by filtration and washing with water and ethanol to yield a light yellow solid (0.96 g, 69%).

Provenance & Evidence