Methyl iodide → HCID 178503353, compound

HRID 1710813Notes

Reaction equation

HRID 1710813 reaction equation
[CH3:1][I:2].[Cl:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]2[C:5]=1[CH:6]([CH3:16])[NH:7][C:8](=[S:15])[NH:9]2>CC(C)=O.C(OCC)C>[IH:2].[Cl:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]2[C:5]=1[CH:6]([CH3:16])[NH:7][C:8]([S:15][CH3:1])=[N:9]2

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 86609752HCID 86609752, compound

Product 1

HCID 178503353HCID 178503353, compoundYield 86.3%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

Methyl iodide (0.73 ml, 11.7 mmol) was added to a suspension of 5,8-dichloro-4-methyl-3,4-dihydro-1H-quinazoline-2-thione (0.96 g, 3.9 mmol) in acetone (12 ml), and the mixture was stirred at room temperature overnight. The reaction was diluted with diethyl ether, and the precipitated product (1.31 g, 86%) was isolated by filtration as a white solid.

Sources & evidence

ORD record
ord-dce822a163894ec5af59f7c95825da56
Source dataset
uspto-grants-2010_09
Patent number
US07790732B2

Reaction notes

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