Hydrogen Peroxide → HCID 178491893, compound

Participants

Reaction Conditions

Reaction Steps

6-Chloro-8-methoxy-4,5-dimethyl-2-methylsulfanyl-3,4-dihydro-quinazoline hydroiodide (119 mg, 0.30 mmol) was suspended in a mixture of ammonium hydroxide (0.22 ml, 25% in H2O, 3 mmol) and acetonitrile (0.9 ml), and heated in a microwave oven to 170° C. (30 min). The reaction was cooled in an ice bath and treated with 1N aqueous sodium hydroxide solution (0.9 ml) and 5-6 drops of concentrated solution of aqueous hydrogen peroxide. A little water was added, and the crude product precipitated and was filtered off. It was purified by column chromatography (silica gel, ethyl acetate/acetone/acetic acid=12/4/1) and was set neutral with 1N aqueous sodium hydroxide solution to yield after drying the title compound as a light grey solid (45 mg, 63%).

Provenance & Evidence