Cesium carbonate → HCID 16222230、化合物

関与物質

反応手順

To a solution of (R)-2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate (1.1 g, 3.58 mmol) in acetone (10 mL) was added 2-(bromomethyl)-4-chloro-1,3-difluorobenzene (0.95 g, 3.94 mmol) followed by the addition of Cs2CO3 (1.28 g, 3.94 mmol). The reaction was stirred at room temperature for 3.5 h and filtered. The solid was rinsed by CH2Cl2 several times. The combined organic layers and filtrate were concentrated and purified by column chromatography on ISCO (40 g) with 0-30% ethyl acetate in hexanes over 25 minutes to yield (R)-2-tert-butyl 1-methyl 6-(3-chloro-2,6-difluorobenzyloxy)-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate as a white foam (1.62 g, 97%). HPLC retention time (Method C)=4.18 min. LC/MS (ESI) (M+H−Boc)+=368.1. 1H NMR (400 MHz, CDCl3) δ ppm 1.48 (d, J=9.67 Hz, 9H), 2.71-2.88 (m, 1H), 2.88-3.07 (m, 1H), 3.70 (s, 4H), 3.72-3.85 (m, 2H), 5.10 (s, 2H), 6.78 (s, 1H), 6.86 (dd, J=8.79, 2.64 Hz, 1H), 6.89-6.97 (m, 1H), 7.33-7.46 (m, 2H).

情報源と証拠