7-Chlorothieno[3,2-B]pyridine-2-carbonitrile → 7-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine-2-carbonitrile

HRID 1710946Notes

Reaction equation

HRID 1710946 reaction equation
[F:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]3SC=C[N:18]=3)[S:13][C:6]=12.ClC1C=CN=C2C=C(C#N)SC=12>>[F:1][C:2]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]2[CH:11]=[C:12]([C:14]#[N:18])[S:13][C:6]=12

Participants

3

Reactant 2

HCID 222786367-Chlorothieno[3,2-B]pyridine-2-carbonitrileHCID 594244257-(2-Fluoro-4-nitrophenoxy)-2-(thiazol-2-yl)thieno[3,2-b]pyridine

Product 1

HCID 594244217-(2-Fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine-2-carbonitrile

Procedure

Following the procedure described above for the synthesis of compound 11 (example 12, step 3, scheme 2) but substituting compound 10 for compound 126, title compound 127 was obtained as a yellow solid (114 mg, 60% yield). MS (m/z) 316.0 (M+H).

Sources & evidence

ORD record
ord-b3d969946d6e4ec48037b930e24c4df6
Source dataset
uspto-grants-2010_09
Patent number
US07790729B2

Reaction notes

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