HCID 86604167, compound → HCID 86604169, compound

HRID 1710950Notes

Reaction equation

HRID 1710950 reaction equation
[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([NH:27][C:28]([NH:30][C:31](=[O:39])[CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[S:29])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]2[CH:16]=[C:17]([C:19]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23]C3)=[O:20])[S:18][C:11]=12.FC1C=C(NC(NC(=O)CC2C=CC=CC=2)=S)C=CC=1OC1C=CN=C2C=C(C(N3CCCCC3)=O)SC=12>>[ClH:1].[F:2][C:3]1[CH:4]=[C:5]([NH:27][C:28]([NH:30][C:31](=[O:39])[CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[S:29])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]2[CH:16]=[C:17]([C:19]([N:21]3[CH2:23][CH2:24][CH2:25][CH2:26]3)=[O:20])[S:18][C:11]=12

Participants

3

Reactant 2

HCID 86604167HCID 86604167, compoundHCID 86604168HCID 86604168, compound

Product 1

HCID 86604169HCID 86604169, compound

Procedure

Following the procedure described above for the synthesis of compound 136a (example 93) but substituting compound 135d (example 92, table 11) for the compound 8o (example 37, table 6), title compound 136b was obtained. Characterization of this material is provided in Table 12.

Sources & evidence

ORD record
ord-e2cf1b5a3fdb43808c005bcafe02fbe8
Source dataset
uspto-grants-2010_09
Patent number
US07790729B2

Reaction notes

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