tert-Butyl 2-(7-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)thieno[3,2-b]pyridine-2-carboxamido)ethyl(methyl)carbamate → Hydrochloric Acid

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Reaction Steps

Following the procedure described above for the synthesis of 137a but replacing compound 135b with compound 138, title compound 137b was obtained as an HCl salt in 65% yield. 1H NMR (400 MHz, DMSO-d6) δ ppm: 12.49 (s, 1H), 11.83 (s, 1H), 9.39(t, J=5.2 Hz, 1H), 8.80(bs, 1H), 8.62(d, J=5.6 Hz, 1H), 8.39 (s, 1H), 8.04(d, J=11.6 Hz, 1H), 7.97(bs, 1H), 7.58-7.50 (m, 2H), 7.37-7.31 (m, 4H), 7.31-7.24 (m, 1H), 6.80(d, J=5.6 Hz, 1H), 3.78-3.71(m, 0.5H), 3.61(q, J=6.0 Hz, 1H), 3.21-3.24 (m, 0.5H), 3.18-3.04 (m, 2H), 2.60(t, J=4.8 Hz, 2H).

Provenance & Evidence