N-(3-Fluoro-4-(2-(4-(methylsulfonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide → N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide

Participants

Reaction Steps

Starting from the amine 169 and following the procedure described above for the synthesis of compound 50 (scheme 10, example 55), title compound 170a was obtained in 29% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm: 12.46 (s, 1H), 11.81 (s, 1H), 8.52(d, J=5.2 Hz, 1H), 8.17(d, J=5.2 Hz, 1H), 8.01(dd, J=2.0 and 11.2 Hz, 1H), 7.60(d, J=5.2 Hz, 1H), 7.58-7.48 (m, 2H), 7.36-7.30 (m, 4H), 7.30-7.22 (m, 1H), 6.64(d, J=5.2 Hz, 1H), 3.82 (s, 2H). LRMS (M+1) 437.5 (100%).

Provenance & Evidence